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Article

A Novel Inhibitor of Translation Initiation Factor eIF5B in Saccharomyces cerevisiae.

Journal of microbiology and biotechnology - 28 Jun 2024

Goh Ah-Ra, Kim Yi-Na, Oh Jae Hyeun, Choi Sang Ki

Abstract excerpt

The eukaryotic translation initiation factor eIF5B is a bacterial IF2 ortholog that plays an important role in ribosome joining and stabilization of the initiator tRNA on the AUG start codon during the initiation of translation. We identified the fluorophenyl oxazole derivative 2,2-dibromo-1-(2-(4-fluorophenyl)benzo[d]oxazol-5-yl)ethanone quinolinol as an inhibitor of fungal protein synthesis using an in vitro...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38755008
DOI: 10.4014/jmb.2404.04015
PMCID: PMC11239407

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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