Article
Structural modeling and mutational analysis of yeast eukaryotic translation initiation factor 5A reveal new critical residues and reinforce its involvement in protein synthesis.
The FEBS journal - 1 Apr 2008
Dias Camila A O, Cano Veridiana S P, Rangel Suzana M, Apponi Luciano H, Frigieri Mariana C, Muniz João R C, Garcia Wanius, Park Myung H, Garratt Richard C, Zanelli Cleslei F, Valentini Sandro R
Abstract excerpt
Eukaryotic translation initiation factor 5A (eIF5A) is a protein that is highly conserved and essential for cell viability. This factor is the only protein known to contain the unique and essential amino acid residue hypusine. This work focused on the structural and functional characterization of Saccharomyces cerevisiae eIF5A. The tertiary structure of yeast eIF5A was modeled based on the structure of its...
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