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Article

Mutations in Caenorhabditis elegans eIF2beta permit translation initiation from non-AUG start codons.

Genetics - 1 May 2010

Zhang Yinhua, Maduzia Lisa L

Abstract excerpt

Recognition of the AUG start codon on mRNAs during translation initiation in eukaryotes occurs in a preinitiation complex that includes small ribosomal subunits and multiple translation initiation factors. The complexity of this process and the lack of appropriate tools have prevented its genetic...

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Identifiers

PMID: 20215469
DOI: 10.1534/genetics.110.115485
PMCID: PMC2870950

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20215469-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Mutations in Caenorhabditis elegans eIF2beta permit translation initiation from non-AUG start codons.PMID 20215469Read ↗

Translation initiation factor 2gamma mutant alters start codon selection independent of Met-tRNA binding.Semantic proximity Read ↗

Mutation analysis of the Cys-X2-Cys-X19-Cys-X2-Cys motif in the beta subunit of eukaryotic translation initiation factor 2.Semantic proximity Read ↗

Identification of compounds that decrease the fidelity of start codon recognition by the eukaryotic translational machinery.Semantic proximity Read ↗

Translation initiation at non-AUG codons mediated by weakened association of eukaryotic initiation factor (eIF) 2 subunits.Semantic proximity Read ↗

Functional elements in initiation factors 1, 1A, and 2β discriminate against poor AUG context and non-AUG start codons.Semantic proximity Read ↗

Translation Initiation Fidelity Defective Mutations in eIF5 and eIF2β Show Distinct Sensitivity to the Sequence Context for Recognition of the UUG Start Codon.Semantic proximity Read ↗

Regulatory elements in eIF1A control the fidelity of start codon selection by modulating tRNA(i)(Met) binding to the ribosome.Semantic proximity Read ↗

IF2 and unique features of initiator tRNAfMet help establish the translational reading frame.Semantic proximity Read ↗

Mutations in GCD11, the structural gene for eIF-2 gamma in yeast, alter translational regulation of GCN4 and the selection of the start site for protein synthesis.Semantic proximity Read ↗

The eIF1A C-terminal domain promotes initiation complex assembly, scanning and AUG selection in vivo.Semantic proximity Read ↗

Conserved residues in yeast initiator tRNA calibrate initiation accuracy by regulating preinitiation complex stability at the start codon.Semantic proximity Read ↗

Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo.Semantic proximity Read ↗

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