Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Translation elongation-3-like factors: are they rational antifungal targets?

Expert opinion on therapeutic targets - 1 Oct 2002

Sturtevant Joy

Abstract excerpt

The occurrence of fungal infection has escalated significantly in recent years and is expected to continue to increase for the foreseeable future. Unfortunately, only a limited number of antifungal drugs are currently available partially due to a lack of suitable targets. The most commonly used antifungals target the same molecule in the cell membrane and, while efficacious, are either extremely toxic or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal Agents
Share to Candida
Share to Drug Resistance, Fungal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Targeting

Share to Mycoses

Share to Peptide Elongation Factor 1

Share to Peptide Elongation Factors

Share to Prions

Source

Identifiers

PMID: 12387678
DOI: 10.1517/14728222.6.5.545

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Translation elongation-3-like factors: are they rational antifungal targets?PMID 12387678Read ↗

Translation elongation factor 2 is part of the target for a new family of antifungals.Semantic proximity Read ↗

Species-specific inhibition of fungal protein synthesis by sordarin: identification of a sordarin-specificity region in eukaryotic elongation factor 2 The GenBank accession numbers for the sequences reported in this manuscript are AF107286–AF107291, AF292693 and AF248644.Semantic proximity Read ↗

Mutations in the chromodomain-like insertion of translation elongation factor 3 compromise protein synthesis through reduced ATPase activity.Semantic proximity Read ↗

Translational elongation factor 3 (EF-3): a study of its structural and functional divergence in fungi.Semantic proximity Read ↗

Functional interactions between yeast translation eukaryotic elongation factor (eEF) 1A and eEF3.Semantic proximity Read ↗

A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.Semantic proximity Read ↗

Developing novel antifungals: lessons from G protein-coupled receptorsSemantic proximity Read ↗

Innovations in Antifungal Drug Discovery among Cell Envelope Synthesis Enzymes through Structural InsightsSemantic proximity Read ↗

Comparative genomics allowed the identification of drug targets against human fungal pathogensSemantic proximity Read ↗

Ribosomal P-protein stalk function is targeted by sordarin antifungals.Semantic proximity Read ↗

Protein synthesis in yeast. Structural and functional analysis of the gene encoding elongation factor 3.Semantic proximity Read ↗

The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.