Article
Identification of compounds that decrease the fidelity of start codon recognition by the eukaryotic translational machinery.
RNA (New York, N.Y.) - 1 Mar 2011
Takacs Julie E, Neary Timothy B, Ingolia Nicholas T, Saini Adesh K, Martin-Marcos Pilar, Pelletier Jerry, Hinnebusch Alan G, Lorsch Jon R
Abstract excerpt
Translation initiation in eukaryotes involves more than a dozen protein factors. Alterations in six factors have been found to reduce the fidelity of start codon recognition by the ribosomal preinitiation complex in yeast, a phenotype referred to as Sui(-). No small molecules are known that affect the fidelity of start codon recognition. Such compounds would be useful tools for probing the molecular mechanics of...
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