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Article

Identification of compounds that decrease the fidelity of start codon recognition by the eukaryotic translational machinery.

RNA (New York, N.Y.) - 1 Mar 2011

Takacs Julie E, Neary Timothy B, Ingolia Nicholas T, Saini Adesh K, Martin-Marcos Pilar, Pelletier Jerry, Hinnebusch Alan G, Lorsch Jon R

Abstract excerpt

Translation initiation in eukaryotes involves more than a dozen protein factors. Alterations in six factors have been found to reduce the fidelity of start codon recognition by the ribosomal preinitiation complex in yeast, a phenotype referred to as Sui(-). No small molecules are known that affec...

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Source

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Identifiers

PMID: 21220547
DOI: 10.1261/rna.2475211
PMCID: PMC3039144

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21220547-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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