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Article

Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2.

Molecular and cellular biology - 1 Oct 2000

Choi S K, Olsen D S, Roll-Mecak A, Martung A, Remo K L, Burley S K, Hinnebusch A G, Dever T E

Abstract excerpt

To initiate protein synthesis, a ribosome with bound initiator methionyl-tRNA must be assembled at the start codon of an mRNA. This process requires the coordinated activities of three translation initiation factors (IF) in prokaryotes and at least 12 translation initiation factors in eukaryotes (eIF). The factors eIF1A and eIF5B from eukaryotes show extensive amino acid sequence similarity to the factors IF1 and...

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Source

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Identifiers

PMID: 10982835
DOI: 10.1128/MCB.20.19.7183-7191.2000
PMCID: PMC86272

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2.PMID 10982835Read ↗

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