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Article

Translation elongation factor 2 is part of the target for a new family of antifungals.

Antimicrobial agents and chemotherapy - 1 Oct 1998

Capa L, Mendoza A, Lavandera J L, Gómez de las Heras F, García-Bustos J F

Abstract excerpt

Translation elongation factor 2 (EF2), which in Saccharomyces cerevisiae is expressed from the EFT1 and EFT2 genes, has been found to be targeted by a new family of highly specific antifungal compounds derived from the natural product sordarin. Two complementation groups of mutants resistant to the semisynthetic sordarin derivative GM193663 were found. The major one (21 members) consisted of isolates with...

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Identifiers

PMID: 9756779
DOI: 10.1128/AAC.42.10.2694
PMCID: PMC105921

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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