Translation elongation factor 2 is part of the target for a new family of antifungals.

doi:10.1128/AAC.42.10.2694

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Article

Translation elongation factor 2 is part of the target for a new family of antifungals.

Antimicrobial agents and chemotherapy - 1 Oct 1998

Capa L, Mendoza A, Lavandera J L, Gómez de las Heras F, García-Bustos J F

Abstract excerpt

Translation elongation factor 2 (EF2), which in Saccharomyces cerevisiae is expressed from the EFT1 and EFT2 genes, has been found to be targeted by a new family of highly specific antifungal compounds derived from the natural product sordarin. Two complementation groups of mutants resistant to t...

Topics

Amino Acid Sequence
Antifungal Agents
Binding Sites
Drug Resistance, Microbial
Indenes
Molecular Sequence Data
Mutation
Peptide Elongation Factor 2
Peptide Elongation Factors

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