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Article

Discovery of chemical modulators of a conserved translational control pathway by parallel screening in yeast.

Assay and drug development technologies - 1 Oct 2009

Motlekar Nuzhat, de Almeida Rogerio Alves, Pavitt Graham D, Diamond Scott L, Napper Andrew D

Abstract excerpt

Eukaryotic initiation factor 2 (eIF2) B is a guanine nucleotide exchange factor that plays a central role in translation initiation and its control, especially in response to diverse cellular stresses. In addition, inherited mutations in human eIF2B subunits cause a fatal brain disorder commonly called childhood ataxia with central nervous system hypomyelination or leukoencephalopathy with vanishing white matter....

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Identifiers

PMID: 19715453
DOI: 10.1089/adt.2009.0198
PMCID: PMC2980340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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