Article
Alcohols inhibit translation to regulate morphogenesis in C. albicans.
Fungal genetics and biology : FG & B - 1 Apr 2015
Egbe Nkechi E, Paget Caroline M, Wang Hui, Ashe Mark P
Abstract excerpt
Many molecules are secreted into the growth media by microorganisms to modulate the metabolic and physiological processes of the organism. For instance, alcohols like butanol, ethanol and isoamyl alcohol are produced by the human pathogenic fungus, Candida albicans and induce morphological differentiation. Here we show that these same alcohols cause a rapid inhibition of protein synthesis. More specifically, the...
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