Article
Novel small-molecule inhibitors of RNA polymerase III.
Eukaryotic cell - 1 Apr 2003
Wu Liping, Pan Jing, Thoroddsen Vala, Wysong Deborah R, Blackman Ronald K, Bulawa Christine E, Gould Alexandra E, Ocain Timothy D, Dick Lawrence R, Errada Patrick, Dorr Patrick K, Parkinson Tanya, Wood Tony, Kornitzer Daniel, Weissman Ziva, Willis Ian M, McGovern Karen
Abstract excerpt
A genetic approach utilizing the yeast Saccharomyces cerevisiae was used to identify the target of antifungal compounds. This analysis led to the identification of small molecule inhibitors of RNA polymerase (Pol) III from Saccharomyces cerevisiae. Three lines of evidence show that UK-118005 inhi...
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