Article
Cryo-EM structures of the human Elongator complex at work.
Nature communications - 15 May 2024
Abbassi Nour-El-Hana, Jaciuk Marcin, Scherf David, Böhnert Pauline, Rau Alexander, Hammermeister Alexander, Rawski Michał, Indyka Paulina, Wazny Grzegorz, Chramiec-Głąbik Andrzej, Dobosz Dominika, Skupien-Rabian Bozena, Jankowska Urszula, Rappsilber Juri, Schaffrath Raffael, Lin Ting-Yu, Glatt Sebastian
Abstract excerpt
tRNA modifications affect ribosomal elongation speed and co-translational folding dynamics. The Elongator complex is responsible for introducing 5-carboxymethyl at wobble uridine bases (cm5U34) in eukaryotic tRNAs. However, the structure and function of human Elongator remain poorly understood. In this study, we present a series of cryo-EM structures of human ELP123 in complex with tRNA and cofactors at four...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.