Article
Impact of different mutations on Kelch13 protein levels, ART resistance, and fitness cost in Plasmodium falciparum parasites.
mBio - 12 Jun 2024
Behrens Hannah M, Schmidt Sabine, Henshall Isabelle G, López-Barona Patricia, Peigney Domitille, Sabitzki Ricarda, May Jürgen, Maïga-Ascofaré Oumou, Spielmann Tobias
Abstract excerpt
Reduced susceptibility to ART, the first-line treatment against malaria, is common in South East Asia (SEA). It is associated with point mutations, mostly in kelch13 (k13) but also in other genes, like ubp1. K13 and its compartment neighbors (KICs), including UBP1, are involved in endocytosis of host cell cytosol. We tested 135 mutations in KICs but none conferred ART resistance. Double mutations of k13C580Y with...
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