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Article

Plasmodium falciparum non-synonymous Kelch13 mutations mediating artemisinin resistance in East Africa: A systematic review and meta-analysis: 2014-2024.

PloS one - 1 Jan 2026

Kapesa Anthony, Baraka Vito, Mwaiswelo Richard, Zinga Maria, Marwa Karol J, Kweka Eliningaya J, Kamugisha Erasmus

Abstract excerpt

BACKGROUND: Resistance to antimalarial drugs has posed a significant challenge to global efforts to control and eliminate malaria. Partial artemisinin resistance has been observed in East Africa, a region that has been a historical hotspot for antimalarial drug resistance across the continent. Consequently, this review assesses the extent of non-synonymous mutations mediating artemisinin resistance, the varieties...

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Identifiers

PMID: 42520053
DOI: 10.1371/journal.pone.0354429
PMCID: PMC13411923

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