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Article

A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites.

Science (New York, N.Y.) - 3 Jan 2020

Birnbaum Jakob, Scharf Sarah, Schmidt Sabine, Jonscher Ernst, Hoeijmakers Wieteke Anna Maria, Flemming Sven, Toenhake Christa Geeke, Schmitt Marius, Sabitzki Ricarda, Bergmann Bärbel, Fröhlke Ulrike, Mesén-Ramírez Paolo, Blancke Soares Alexandra, Herrmann Hendrik, Bártfai Richárd, Spielmann Tobias

Abstract excerpt

Artemisinin and its derivatives (ARTs) are the frontline drugs against malaria, but resistance is jeopardizing their effectiveness. ART resistance is mediated by mutations in the parasite's Kelch13 protein, but Kelch13 function and its role in resistance remain unclear. In this study, we identified proteins located at a Kelch13-defined compartment. Inactivation of eight of these proteins, including Kelch13,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 31896710
DOI: 10.1126/science.aax4735

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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