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Article

The Kelch13 compartment contains highly divergent vesicle trafficking proteins in malaria parasites.

PLoS pathogens - 1 Dec 2023

Schmidt Sabine, Wichers-Misterek Jan Stephan, Behrens Hannah Michaela, Birnbaum Jakob, Henshall Isabelle G, Dröge Jana, Jonscher Ernst, Flemming Sven, Castro-Peña Carolina, Mesén-Ramírez Paolo, Spielmann Tobias

Abstract excerpt

Single amino acid changes in the parasite protein Kelch13 (K13) result in reduced susceptibility of P. falciparum parasites to artemisinin and its derivatives (ART). Recent work indicated that K13 and other proteins co-localising with K13 (K13 compartment proteins) are involved in the endocytic uptake of host cell cytosol (HCCU) and that a reduction in HCCU results in reduced susceptibility to ART. HCCU is...

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Identifiers

PMID: 38039338
DOI: 10.1371/journal.ppat.1011814
PMCID: PMC10718435

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