Article
K13, the Cytostome, and Artemisinin Resistance.
Trends in parasitology - 1 Jun 2020
Xie Stanley C, Ralph Stuart A, Tilley Leann
Abstract excerpt
Artemisinins - the frontline antimalarial drug class - are compromised by emerging resistance, putting at risk the lives of hundreds of thousands of people each year. Resistance is associated with mutations in a malaria parasite protein, called Kelch 13 (K13). Recent work suggests that K13 is located at the cytostome (cell mouth) that the parasite uses to take up hemoglobin. Here we explore the proposal that K13...
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