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Article

What exactly does the PfK13 C580Y mutation in Plasmodium falciparum influence?

Parasites & vectors - 16 Nov 2023

Si Wenwen, Zhao Yuemeng, Qin Xixi, Huang Yixuan, Yu Jing, Liu Xiao, Li Yanna, Yan Xiaoli, Zhang Qingfeng, Sun Jun

Abstract excerpt

BACKGROUND: The emergence and spread of artemisinin resistance threaten global malaria control and elimination goals, and encourage research on the mechanisms of drug resistance in malaria parasites. Mutations in Plasmodium falciparum Kelch 13 (PfK13) protein are associated with artemisinin resistance, but the unique or common mechanism which results in this resistance is unclear. METHODS: We analyzed the effects...

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Identifiers

PMID: 37974285
DOI: 10.1186/s13071-023-06024-4
PMCID: PMC10652512

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