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Article

Fitness Costs and the Rapid Spread of kelch13-C580Y Substitutions Conferring Artemisinin Resistance.

Antimicrobial agents and chemotherapy - 1 Sept 2018

Nair Shalini, Li Xue, Arya Grace A, McDew-White Marina, Ferrari Marco, Nosten François, Anderson Tim J C

Abstract excerpt

Fitness costs are key determinants of whether drug resistance alleles establish and how fast they spread within populations. More than 125 different kelch13 alleles, each containing a different amino acid substitution, have arisen in Southeast Asian malaria parasite (Plasmodium falciparum) populations under artemisinin selection over the past 15 years in a dramatic example of a soft selective event. However, just...

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Identifiers

PMID: 29914963
DOI: 10.1128/AAC.00605-18
PMCID: PMC6125530

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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