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Article

The newly discovered role of endocytosis in artemisinin resistance.

Medicinal research reviews - 1 Nov 2021

Behrens Hannah Michaela, Schmidt Sabine, Spielmann Tobias

Abstract excerpt

Artemisinin and its derivatives (ART) are the cornerstone of malaria treatment as part of artemisinin combination therapy (ACT). However, reduced susceptibility to artemisinin as well as its partner drugs threatens the usefulness of ACTs. Single point mutations in the parasite protein Kelch13 (K13) are necessary and sufficient for the reduced sensitivity of malaria parasites to ART but several alternative...

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Identifiers

PMID: 34309894
DOI: 10.1002/med.21848

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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