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Article

Rationalization design, soluble expression and PEG modification of highly active recombinant human-porcine uricase mutant protein.

International journal of biological macromolecules - 1 Jun 2024

Tong Mingjie, Wang Shengli, Luan Junxi, Xie Qiuling, Wang Luquan, Shen Xiaoyang, Xiong Sheng

Abstract excerpt

Uric acid is the end product of purine metabolism in humans due to inactivation of the uricase determined by the mutated uricase gene. Uricase catalyzes the conversion of uric acid into water-soluble allantoin that is easily excreted by the kidneys. Hyperuricemia occurs when the serum concentration of uric acid exceeds its solubility (7 mg/dL). However, modifications to improve the uricase activity is under...

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Identifiers

PMID: 38697425
DOI: 10.1016/j.ijbiomac.2024.131989

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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