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Engineering Human Urate Oxidase: Towards Reactivating It as an Important Therapeutic Enzyme.

Current pharmaceutical biotechnology - 1 Jan 2015

Dabbagh Fatemeh, Ghoshoon Mohammad B, Hemmati Shiva, Zamani Mozhdeh, Mohkam Milad, Ghasemi Younes

Abstract excerpt

Urate oxidase is considered as an important therapeutic enzyme used to control hyperuricemia. In spite of widespread distribution in numerous (micro)organisms, active urate oxidase is absent in higher primates (humans and apes) due to gene mutations. Considering the therapeutic significance of urate oxidase, further understanding on the inactivation process of the enzyme during primate evolution is critical. This...

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PMID: 26343133
DOI: 10.2174/1389201016666150907113055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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