Article

In Vivo Study of Newly Developed Albumin-Conjugated Urate Oxidase for Gout Treatment

2023-10-24

Abstract excerpt

<h4>Background: </h4> Exogenously providing engineered Uox with enhanced half-life is one of the important urate-lowering treatments for gout. The potential of PAT101, a recombinant human albumin (rHA)-conjugated variant, was evaluated and compared as a novel gout treatment through various in vivo studies with PAT101 and competing drugs. <h4>Methods: </h4>: PAT101 was produced by site-specific conjugation of rHA...

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Literature Corpus work: 3a8822e1-9cd5-5a76-9547-0f015056fac3
DOI: 10.21203/rs.3.rs-3460642/v1

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