Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Knockout of the urate oxidase gene provides a stable mouse model of hyperuricemia associated with metabolic disorders.

Kidney international - 1 Jan 2018

Lu Jie, Hou Xu, Yuan Xuan, Cui Lingling, Liu Zhen, Li Xinde, Ma Lidan, Cheng Xiaoyu, Xin Ying, Wang Can, Zhang Keke, Wang Xuefeng, Ren Wei, Sun Ruixia, Jia Zhaotong, Tian Zibin, Mi Qing-Sheng, Li Changgui

Abstract excerpt

The urate oxidase (Uox) gene encodes uricase that in the rodent liver degrades uric acid into allantoin, forming an obstacle for establishing stable mouse models of hyperuricemia. The loss of uricase in humans during primate evolution causes their vulnerability to hyperuricemia. Thus, we generated a Uox-knockout mouse model on a pure C57BL/6J background using the transcription activator-like effector nuclease...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Glucose
Share to Blood Urea Nitrogen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Creatinine

Share to Diabetes Mellitus, Experimental

Share to Dyslipidemias

Share to Gout Suppressants

Share to Hyperuricemia

Share to Uric Acid

Source

Identifiers

PMID: 28729031
DOI: 10.1016/j.kint.2017.04.031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Knockout of the urate oxidase gene provides a stable mouse model of hyperuricemia associated with metabolic disorders.PMID 28729031Read ↗

CRISPR/Cas9 Mediated Deletion of the Uox Gene Generates a Mouse Model of Hyperuricemia with Multiple Complications.Semantic proximity Read ↗

The Role of Uric Acid in Human Health: Insights from the Uricase GeneSemantic proximity Read ↗

Targeting Liver Xor by GalNAc-siRNA Is an Effective Strategy for Hyperuricemia TherapySemantic proximity Read ↗

Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiencySemantic proximity Read ↗

Mouse models for human hyperuricaemia: a critical reviewSemantic proximity Read ↗

hURAT1 Transgenic Mouse Model for Evaluating Targeted Urate-Lowering Agents.Semantic proximity Read ↗

Uric acid: a danger signal from the RNA world that may have a role in the epidemic of obesity, metabolic syndrome, and cardiorenal disease: evolutionary considerations.Semantic proximity Read ↗

Deficiency of 5-hydroxyisourate hydrolase causes hepatomegaly and hepatocellular carcinoma in mice.Semantic proximity Read ↗

<i>hURAT1</i> Transgenic Mouse Model for Evaluating Targeted Urate-Lowering AgentsSemantic proximity Read ↗

Hyperuricemia during Pregnancy Leads to a Preeclampsia-Like Phenotype in Mice.Semantic proximity Read ↗

Serum Amino Acid Alterations in Hyperuricemia: Potential Targets for Renal Disease PreventionSemantic proximity Read ↗

[Urate transporter and renal hypouricemia].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.