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Article

CRISPR/Cas9 Mediated Deletion of the Uox Gene Generates a Mouse Model of Hyperuricemia with Multiple Complications.

Journal of cardiovascular translational research - 1 Dec 2024

Zeng Linzi, Shali Shalaimaiti, Gao Yabiao, Du Xingchen, Zhu Xiaoxia, Li Lin, Dai Yuxiang, Zhou Ping

Abstract excerpt

Hyperuricemia is a common metabolic disorder with severe complications. We aimed to develop a mouse model for spontaneous hyperuricemia. Uox-/- mouse model was generated on C57BL/6J background by deleting exon 2-4 of Uox using the CRISPR/Cas9 system. The prototypic Uox -/-mice had 5.5-fold increased serum uric acid (1351.04±276.58μmol/L) as compared to the wild type mice (P<0.0001), but died by 4 weeks. After...

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Identifiers

PMID: 38856882
DOI: 10.1007/s12265-024-10526-6
PMCID: PMC11635051

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