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Article

Structure-based characterization of canine-human chimeric uricases and its evolutionary implications.

Biochimie - 1 Jun 2012

Zhang Chun, Fan Kai, Zhang Weitao, Zhu Ruixin, Zhang Lujia, Wei Dongzhi

Abstract excerpt

Uricase was lost in hominoids during primate evolution, but the inactivation mechanism remains controversial. To investigate the inactivation process of hominoid uricase, chimeric constructions between canine and human uricase were employed to screen the target regions that may contain labile or inactivated mutations in deduced human uricase. Four chimeric uricases were constructed and showed different enzymatic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 22481018
DOI: 10.1016/j.biochi.2012.03.016

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CAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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