Article

The Role of Uric Acid in Human Health: Insights from the Uricase Gene

2023-08-24

Abstract excerpt

The accumulation of loss of function mutations in the uricase gene well explains the high urate levels in hominoids (apes and humans) compared to other mammals. The loss of human uricase activity may have allowed humans to survive environmental stressors, evolution bottlenecks, and life-threatening pathogens. While high urate levels may contribute to developing cardiometabolic disorders such as hypertension and in...

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Literature Corpus work: b6b6c465-c774-53d0-9976-df34308da07d
DOI: 10.20944/preprints202308.1703.v1

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