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Article

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest

13 Sept 2004

Abstract excerpt

Bloom's syndrome is a rare autosomal recessive genetic disorder characterized by chromosomal aberrations, genetic instability, and cancer predisposition, all of which may be the result of abnormal signal transduction during DNA damage recognition. Here, we show that BLM is an intermediate responder to stalled DNA replication forks. BLM colocalized and physically interacted with the DNA damage response proteins...

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Identifiers

PMID: 15364958
DOI: 10.1083/jcb.200405128

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrestPMID 15364958Read ↗

A novel cell-cycle-regulated interaction of the Bloom syndrome helicase BLM with Mcm6 controls replication-linked processes.Semantic proximity Read ↗

Regulation and Localization of the Bloom Syndrome Protein in Response to DNA DamageSemantic proximity Read ↗

ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activation and 53BP1 focus formation.Semantic proximity Read ↗

Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks.Semantic proximity Read ↗

Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrestSemantic proximity Read ↗

Bloom syndrome, genomic instability and cancer: the SOS-like hypothesis.Semantic proximity Read ↗

Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest.Semantic proximity Read ↗

Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification.Semantic proximity Read ↗

Bloom helicase and DNA topoisomerase IIIalpha are involved in the dissolution of sister chromatids.Semantic proximity Read ↗

Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51.Semantic proximity Read ↗

TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.Semantic proximity Read ↗

Bloom syndrome and the underlying causes of genetic instability.Semantic proximity Read ↗

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