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Article

MCM5 UFMylation regulates replication origin firing and fork progression.

The EMBO journal - 1 Nov 2025

Li Zheng, Wu Xingxuan, Liu Liu, Rao Shaohong, Liao Yanting, Liu Mengting, Peng Bin, Zhang Qiongdan, Xia Yisui, Zhai Yuanliang, Takeda Shunichi, Xu Xingzhi

Abstract excerpt

Modification with UFM1 (UFMylation) is essential for cell proliferation, but its precise mechanism of action is unclear. Furthermore, the UFMylation pathway has been associated with microcephalic primordial dwarfism (MPD) disorders, and mutations causative for MPD are also identified in genes encoding components of the replicative DNA helicase complex, including the MCM hexamer. Here, we reveal that UFMylation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 40940420
DOI: 10.1038/s44318-025-00562-6
PMCID: PMC12583452

Genes

MCM5
UFM1
UFL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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