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Article

Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation.

Nature communications - 1 Jan 2013

Min WooKee, Bruhn Christopher, Grigaravicius Paulius, Zhou Zhong-Wei, Li Fu, Krüger Anja, Siddeek Bénazir, Greulich Karl-Otto, Popp Oliver, Meisezahl Chris, Calkhoven Cornelis F, Bürkle Alexander, Xu Xingzhi, Wang Zhao-Qi

Abstract excerpt

Damaged replication forks activate poly(ADP-ribose) polymerase 1 (PARP1), which catalyses poly(ADP-ribose) (PAR) formation; however, how PARP1 or poly(ADP-ribosyl)ation is involved in the S-phase checkpoint is unknown. Here we show that PAR, supplied by PARP1, interacts with Chk1 via a novel PAR-...

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Source

Identifiers

PMID: 24356582
DOI: 10.1038/ncomms3993

Genes

PARP1
ATR
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24356582-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation.PMID 24356582Read ↗

Poly(ADP-ribosyl) glycohydrolase prevents the accumulation of unusual replication structures during unperturbed S phase.Semantic proximity Read ↗

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The oncoprotein DEK affects the outcome of PARP1/2 inhibition during replication stressSemantic proximity Read ↗

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Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells.Semantic proximity Read ↗

HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation ActivitySemantic proximity Read ↗

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