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Article

Targeting the checkpoint kinase Chk1 in cancer therapy

15 Jan 2010

Abstract excerpt

A paramount objective of the eukaryotic cell division cycle is to overcome numerous internal and external insults to faithfully duplicate the genetic information once per every cycle. This is carried out by elaborate networks of genome surveillance signaling pathways, termed replication checkpoints. Central to replication checkpoints are two protein kinases, the upstream kinase ATR, and its downstream target...

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Identifiers

PMID: 20023404
DOI: 10.4161/cc.9.2.10445

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