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Article

Actin polymerization-driven molecular movement of mDia1 in living cells.

Science (New York, N.Y.) - 26 Mar 2004

Higashida Chiharu, Miyoshi Takushi, Fujita Akiko, Oceguera-Yanez Fabian, Monypenny James, Andou Yoshikazu, Narumiya Shuh, Watanabe Naoki

Abstract excerpt

mDia1, a Rho effector, belongs to the Formin family of proteins, which shares the conserved tandem FH1-FH2 unit structure. Formins including mDia1 accelerate actin nucleation while interacting with actin filament fast-growing ends. Here our single-molecule imaging revealed fast directional movement of mDia1 FH1-FH2 for tens of microns in living cells. The movement of mDia1 FH1-FH2 was blocked by actin-perturbing...

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Identifiers

PMID: 15044801
DOI: 10.1126/science.1093923

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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