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Article

Cofilin cross-bridges adjacent actin protomers and replaces part of the longitudinal F-actin interface.

Journal of molecular biology - 5 May 2006

Kudryashov D S, Galkin V E, Orlova A, Phan M, Egelman E H, Reisler E

Abstract excerpt

ADF/cofilins are abundant actin binding proteins critical to the survival of eukaryotic cells. Most ADF/cofilins bind both G and F-actin, sever the filaments and accelerate their treadmilling. These effects are linked to rearrangements of interprotomer contacts, changes in the mean twist, and filament destabilization by ADF/cofilin. Paradoxically, it was reported that under certain in vitro and in vivo conditions...

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PMID: 16530787
DOI: 10.1016/j.jmb.2006.02.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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