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Article

Helical rotation of the diaphanous-related formin mDia1 generates actin filaments resistant to cofilin.

Proceedings of the National Academy of Sciences of the United States of America - 29 May 2018

Mizuno Hiroaki, Tanaka Kotaro, Yamashiro Sawako, Narita Akihiro, Watanabe Naoki

Abstract excerpt

The complex interplay between actin regulatory proteins facilitates the formation of diverse cellular actin structures. Formin homology proteins (formins) play an essential role in the formation of actin stress fibers and yeast actin cables, to which the major actin depolymerizing factor cofilin barely associates. In vitro, F-actin decorated with cofilin exhibits a marked increase in the filament twist. On the...

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Identifiers

PMID: 29760064
DOI: 10.1073/pnas.1803415115
PMCID: PMC5984536

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Helical rotation of the diaphanous-related formin mDia1 generates actin filaments resistant to cofilin.PMID 29760064Read ↗

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