Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: A meta-analysis within diverse populations.

doi:10.7554/eLife.78304

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: A meta-analysis within diverse populations.

eLife - 8 Jul 2022

Chen Fei, Darst Burcu F, Madduri Ravi K, Rodriguez Alex A, Sheng Xin, Rentsch Christopher T, Andrews Caroline, Tang Wei, Kibel Adam S, Plym Anna, Cho Kelly, Jalloh Mohamed, Gueye Serigne Magueye, Niang Lamine, Ogunbiyi Olufemi J, Popoola Olufemi, Adebiyi Akindele O, Aisuodionoe-Shadrach Oseremen I, Ajibola Hafees O, Jamda Mustapha A, Oluwole Olabode P, Nwegbu Maxwell, Adusei Ben, Mante Sunny, Darkwa-Abrahams Afua, Mensah James E, Adjei Andrew Anthony, Diop Halimatou, Lachance Joseph, Rebbeck Timothy R, Ambs Stefan, Gaziano J Michael, Justice Amy C, Conti David V, Haiman Christopher A

Abstract excerpt

Background: We recently developed a multi-ancestry polygenic risk score (PRS) that effectively stratifies prostate cancer risk across populations. In this study, we validated the performance of the PRS in the multi-ancestry Million Veteran Program and additional independent studies. Methods: Within each ancestry population, the association of PRS with prostate cancer risk was evaluated separately in each...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Multifactorial Inheritance

Share to Prostatic Neoplasms

Share to Risk Factors

Share to United States

Source

Open in PubMed Open full text

Identifiers

PMID: 35801699
DOI: 10.7554/eLife.78304
PMCID: PMC9322982

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: A meta-analysis within diverse populations.PMID 35801699Read ↗

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.Semantic proximity Read ↗

Validation and context-dependent effects of a prostate cancer polygenic risk score in the All of Us Research Program.Semantic proximity Read ↗

Validation and context-dependent effects of a prostate cancer polygenic risk score in the All of Us Research ProgramSemantic proximity Read ↗

Evaluation of a Multiethnic Polygenic Risk Score Model for Prostate Cancer.Semantic proximity Read ↗

Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.Semantic proximity Read ↗

Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups.Semantic proximity Read ↗

PRState: Incorporating genetic ancestry in prostate cancer risk scores for men of African ancestry.Semantic proximity Read ↗

Benchmarking multi-ancestry prostate cancer polygenic risk scores in a real-world cohort.Semantic proximity Read ↗

Evaluating approaches for constructing polygenic risk scores for prostate cancer in men of African and European ancestry.Semantic proximity Read ↗

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.Semantic proximity Read ↗

The Impact of African Ancestry on Prostate Cancer Disparities in the Era of Precision MedicineSemantic proximity Read ↗

Polygenic risk for prostate cancer: Decreasing relative risk with age but little impact on absolute risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.