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Article

Validation and context-dependent effects of a prostate cancer polygenic risk score in the All of Us Research Program.

American journal of human genetics - 5 Feb 2026

Cheng Shuyan, Suger Austin Hammermeister, Goss Louisa B, Zhang Jiachen, Fuller Harriett, Guo Boya, Lindström Sara, Darst Burcu F

Abstract excerpt

Polygenic risk scores (PRSs) have demonstrated strong potential for improving prostate cancer risk stratification. However, it is unknown whether the clinical utility of prostate cancer PRS varies by demographic, lifestyle, and socioeconomic factors. We validated a previously developed multi-ancestry PRS of 451 prostate cancer risk variants and evaluated context-dependent effects using genetic and clinical data...

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Identifiers

PMID: 41650938
DOI: 10.1016/j.ajhg.2026.01.002
PMCID: PMC12993797

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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