Article

Validation and context-dependent effects of a prostate cancer polygenic risk score in the All of Us Research Program

2025-10-03

Abstract excerpt

Polygenic risk scores (PRSs) have demonstrated strong potential for improving prostate cancer risk stratification. However, it is unknown whether the clinical utility of prostate cancer PRS vary by demographic, lifestyle, and socioeconomic factors. We validated a previously developed multi-ancestry PRS of 451 prostate cancer risk variants and evaluated context-dependent effects using genetic and clinical data from...

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Literature Corpus work: 174e4019-6c3a-5492-8590-ead23d47c880
DOI: 10.1101/2025.10.01.25337107

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