Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers.

BMC neurology - 9 Apr 2024

Lane Roger M, Darreh-Shori Taher, Junge Candice, Li Dan, Yang Qingqing, Edwards Amanda L, Graham Danielle L, Moore Katrina, Mummery Catherine J

Abstract excerpt

BACKGROUND: The authors sought to examine the impact of the K-variant of butyrylcholinesterase (BCHE-K) carrier status on age-at-diagnosis of Alzheimer disease (AD) in APOE4 carriers. METHODS: Patients aged 50-74 years with cerebrospinal fluid (CSF) biomarker-confirmed AD, were recruited to clinical trial (NCT03186989 since June 14, 2017). Baseline demographics, disease characteristics, and biomarkers were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoprotein E4

Share to Apolipoproteins E

Share to Butyrylcholinesterase

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 38594621
DOI: 10.1186/s12883-024-03611-5
PMCID: PMC11003149

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers.PMID 38594621Read ↗

Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriersSemantic proximity Read ↗

Glial activation mediates phenotypic effects of<i>APOEε4</i>and sex in Alzheimer’s diseaseSemantic proximity Read ↗

Butyrylcholinesterase K variant and Alzheimer's disease risk: a meta-analysis.Semantic proximity Read ↗

Butyrylcholinesterase genotype and gender influence Alzheimer's disease phenotype.Semantic proximity Read ↗

Age-dependent association between butyrylcholinesterase K-variant and Alzheimer disease-related neuropathology in human brains.Semantic proximity Read ↗

Apolipoprotein ε4 modulates phenotype of butyrylcholinesterase in CSF of patients with Alzheimer's disease.Semantic proximity Read ↗

Association of Butyrylcholinesterase-K Allele and Apolipoprotein E ɛ4 Allele with Cognitive Decline in Dementia with Lewy Bodies and Alzheimer's Disease.Semantic proximity Read ↗

Neurodevelopment and neural environment inform Alzheimer's disease age at onset and phenotype.Semantic proximity Read ↗

Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study.Semantic proximity Read ↗

Characterizing the Preclinical Stages of Alzheimer's Disease and the Prospect of Presymptomatic InterventionSemantic proximity Read ↗

APOE <i>ε</i> 4-Associated Hippocampal Atrophy Trajectories Across the Alzheimer’s Disease Continuum: A Systematic Review, Meta-Analysis, and Longitudinal ValidationSemantic proximity Read ↗

Beyond Lipidation: CSF APOE4 Protein Burden, Not HDL Subclass, Drives Tau Associations in APOE4 Alzheimer’s DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.