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Article

Apolipoprotein ε4 modulates phenotype of butyrylcholinesterase in CSF of patients with Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2012

Darreh-Shori Taher, Siawesh Manar, Mousavi Malahat, Andreasen Niels, Nordberg Agneta

Abstract excerpt

Butyrylcholinesterase K (BCHE-K) is associated with increased risk of developing Alzheimer's disease (AD) in apolipoprotein ε (APOE4) carriers, while among APOE4 non-carriers BCHE-K appears to be protective. Nonetheless, pure pharmacogenetic reports have provided conflicting results. To provide insights about these controversies, we combined BCHE-K pharmacogenetic observations in AD patients (n = 179) with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22012848
DOI: 10.3233/JAD-2011-111088

Genes

BCHE

Provenance

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Apolipoprotein ε4 modulates phenotype of butyrylcholinesterase in CSF of patients with Alzheimer's disease.PMID 22012848Read ↗

The apolipoprotein E ε4 allele plays pathological roles in AD through high protein expression and interaction with butyrylcholinesterase.Semantic proximity Read ↗

Association between butyrylcholinesterase and cerebrospinal fluid biomarkers in Alzheimer's disease patients.Semantic proximity Read ↗

Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriersSemantic proximity Read ↗

BuChE-K and APOE epsilon4 allele frequencies in Lewy body dementias, and influence of genotype and hyperhomocysteinemia on cognitive decline.Semantic proximity Read ↗

Differential CSF butyrylcholinesterase levels in Alzheimer's disease patients with the ApoE epsilon4 allele, in relation to cognitive function and cerebral glucose metabolism.Semantic proximity Read ↗

Association of Butyrylcholinesterase-K Allele and Apolipoprotein E ɛ4 Allele with Cognitive Decline in Dementia with Lewy Bodies and Alzheimer's Disease.Semantic proximity Read ↗

Butyrylcholinesterase K variant and Alzheimer's disease risk: a meta-analysis.Semantic proximity Read ↗

Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers.Semantic proximity Read ↗

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Analysis of association between butyrylcholinesterase K variant and apolipoprotein E genotypes in Alzheimer's disease.Semantic proximity Read ↗

No differences of butyrylcholinesterase protein activity and allele frequency in Lewy body diseases.Semantic proximity Read ↗

BuChE K variant is decreased in Alzheimer's disease not in fronto-temporal dementia.Semantic proximity Read ↗

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