Article
Neurodevelopment and neural environment inform Alzheimer's disease age at onset and phenotype.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Sept 2025
Miller Zachary A, Ossenkoppele Rik, Graff-Radford Neill R, Allen Isabel E, Shwe Wendy, Rosenberg Lynne, Olguin Dustin J, Erkkinen Michael G, Butler P Monroe, Spina Salvatore, Yokoyama Jennifer S, Desikan Rahul S, Scheltens Philip, van der Flier Wiesje, Pijnenburg Yolande, Wolters Emma, Rademakers Rosa, Geschwind Daniel H, Kramer Joel H, Rosen Howard J, Rankin Katherine P, Grinberg Lea T, Seeley William W, Sturm Virginia, Perry David C, Miller Bruce L, Rabinovici Gil D, Gorno-Tempini Maria Luisa
Abstract excerpt
INTRODUCTION: Risk factors associated with sporadic non-amnestic and early-onset Alzheimer's disease (AD) remain underexamined. METHODS: We investigated a large, clinically heterogeneous, AD cohort for frequencies of established risk factors (hypertension, hypercholesterolemia, diabetes mellitus) alongside novel factors (non-right-handedness, learning disability, seizures, autoimmune disease). RESULTS:...
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