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Structural and functional diversity of asparaginases: Overview and recommendations for a revised nomenclature

24 Feb 2021

Abstract excerpt

Asparaginases (ASNases) are a large and structurally diverse group of enzymes ubiquitous amongst archaea, bacteria and eukaryotes, that catalyze hydrolysis of asparagine to aspartate and ammonia. Bacterial ASNases are important biopharmaceuticals for the treatment of acute lymphoblastic leukemia, although some patients experience adverse allergic side effects during treatment with these protein therapeutics....

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PMID: 33624365
DOI: 10.1002/bab.2127

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