Structural and functional role of Gly281 in L-asparaginase from Erwinia carotovora.

doi:10.2174/092986652012131112120218

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Article

Structural and functional role of Gly281 in L-asparaginase from Erwinia carotovora.

Protein and peptide letters - 1 Dec 2013

Kotzia Georgia A, Labrou Nikolaos E

Abstract excerpt

L-asparaginases (E.C.3.5.1.1, L- ASNases) have been widely used in clinical practice as chemotherapeutic drugs of acute lymphoblastic leukaemia (ALL). In order to evaluate the structural and functional role of selected residues in ASNases we report the screening of a library of L-ASNase mutants aiming to find detrimental mutations that significantly affect catalysis and substrate specificity. The library of...

Topics

Asparaginase
Bacterial Proteins
Directed Molecular Evolution
Enzyme Stability
Hydrogen-Ion Concentration
Models, Molecular
Mutation
Pectobacterium carotovorum
Protein Engineering

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Identifiers

PMID: 24261975
DOI: 10.2174/092986652012131112120218

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