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Article

Structural and functional role of Gly281 in L-asparaginase from Erwinia carotovora.

Protein and peptide letters - 1 Dec 2013

Kotzia Georgia A, Labrou Nikolaos E

Abstract excerpt

L-asparaginases (E.C.3.5.1.1, L- ASNases) have been widely used in clinical practice as chemotherapeutic drugs of acute lymphoblastic leukaemia (ALL). In order to evaluate the structural and functional role of selected residues in ASNases we report the screening of a library of L-ASNase mutants aiming to find detrimental mutations that significantly affect catalysis and substrate specificity. The library of...

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Identifiers

PMID: 24261975
DOI: 10.2174/092986652012131112120218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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