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Structural and biochemical properties of L‐asparaginase

1 Jun 2021

Abstract excerpt

l-Asparaginase (a hydrolase converting l-asparagine to l-aspartic acid) was the first enzyme to be used in clinical practice as an anticancer agent after its approval in 1978 as a component of a treatment protocol for childhood acute lymphoblastic leukemia. Structural and biochemical properties of l-asparaginases have been extensively investigated during the last half-century, providing an accurate structural...

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PMID: 34060231
DOI: 10.1111/febs.16042

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