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Metagenomic discovery and functional validation of L-asparaginases with anti-leukemic effect from the Caspian Sea

1 Jan 2021

Abstract excerpt

By screening 27,000 publicly available prokaryotic genomes, we recovered ca. 6300 type I and ca. 5200 type II putative L-asparaginase highlighting the vast potential of prokaryotes. Caspian water with similar salt composition to the human serum was targeted for in silico L-asparaginase screening. We screened ca. three million predicted genes of its assembled metagenomes that resulted in annotation of 87 putative...

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PMID: 33458619
DOI: 10.1016/j.isci.2020.101973

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