Article

Metagenomic discovery and functional validation of L-asparaginases with anti-leukemic effect from the Caspian Sea

2020-06-15

Abstract excerpt

<title>Abstract</title> <p>Background L-asparaginase has been used for the treatment of acute lymphoblastic leukemia (ALL) for more than 30 years. However, efforts continued to find new enzymes with more desirable properties due to the immunogenicity, short half-life, rapid clearance and L-glutaminase side activity of the existing commercial enzymes. Screening for novel L-asparaginases in prokaryotes as a promis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2dd6fdea-719e-553a-a3b4-ca9a63bd8185
DOI: 10.21203/rs.3.rs-34717/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Metagenomic discovery and functional validation of L-asparaginases with anti-leukemic effect from the Caspian SeaDOI 10.21203/rs.3.rs-34717/v1Read

Metagenomic discovery and functional validation of L-asparaginases with anti-leukemic effect from the Caspian SeaSemantic proximity Read

Structural and functional diversity of asparaginases: Overview and recommendations for a revised nomenclatureSemantic proximity Read

Structure, Substrate Complexation and Reaction Mechanism of Bacterial AsparaginasesSemantic proximity Read

Structural and biochemical properties of L‐asparaginaseSemantic proximity Read

Purification and characterization of glutaminase free asparaginase from Pseudomonas otitidis: Induce apoptosis in human leukemia MOLT-4 cellsSemantic proximity Read

Desirable L-asparaginases for treating cancer and current research trendsSemantic proximity Read

Optimization and characterization of antileukemic L-asparaginase produced by Fusarium solani endophyteSemantic proximity Read

Mutations in asparaginase II from E. coli and implications for inactivation and PEGylation.Semantic proximity Read

Identification and Structural Analysis of an l-Asparaginase Enzyme from Guinea Pig with Putative Tumor Cell Killing PropertiesSemantic proximity Read

Recharacterization of EmAGA, a Potential Candidate for Novel ALL Therapeutics.Semantic proximity Read

The Characterization of L-Asparaginase with Low L-Glutaminase Activity Produced by the Marine Pseudomonas sp. Strain GH-W2bSemantic proximity Read

Update on the Use of L-Asparaginase in Infants and Adolescent Patients with Acute Lymphoblastic LeukemiaSemantic proximity Read