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Article

Comparative immunogenicity and structural analysis of epitopes of different bacterial L-asparaginases

11 Feb 2016

Abstract excerpt

BACKGROUND: E.coli type II L-asparaginase is widely used for treatment of acute lymphoblastic leukemia. However, serious side effects such as allergic or hypersensitivity reactions are common for L-asparaginase treatment. Methods for minimizing immune response on L-asparaginase treatment in human include bioengeneering of less immunogenic version of the enzyme or utilizing the homologous enzymes of different...

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PMID: 26867931
DOI: 10.1186/s12885-016-2125-4

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