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Article

Possible mechanism of metabolic and drug resistance with L-asparaginase therapy in childhood leukaemia

1 Feb 2023

Abstract excerpt

L-asparaginase, which hydrolyzes asparagine into aspartic acid and ammonia, is frequently used to treat acute lymphoblastic leukaemia in children. When combined with other chemotherapy drugs, the event-free survival rate is 90%. Due to immunogenicity and drug resistance, however, not all patients benefit from it, restricting the use of L-asparaginase therapy in other haematological cancers. To solve the problem...

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Identifiers

PMID: 36816964
DOI: 10.3389/fonc.2023.1070069

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