Article
Mutations in asparaginase II from E. coli and implications for inactivation and PEGylation.
Biophysical chemistry - 1 Aug 2023
de Magalhães Mariana T Q, de Araújo Talita Stelling, Silva Bruno Marques, Icart Luis Peña, Scapin Sandra M N, da Silva Almeida Marcius, Lima Luís Maurício T R
Abstract excerpt
All clinically-used asparaginases convert L-asparagine (L-Asn) to l-aspartate (L-Asp) and l-glutamine (L-Gln) to L-glutamate (L-Glu), which has been useful in reducing bioavailable asparagine and glutamine in patients under treatment for acute lymphoblastic leukemia. The E. coli type 2 L-asparaginase (EcA2) can present different sequences among varying bacterial strains, which we hypothesized that might affect...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.