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Diagnostic Challenge and Clinical Dilemma: The Long Reach of Clonal Hematopoiesis.

Clinical chemistry - 5 Aug 2021

Osman Afaf, Patel Jay L

Abstract excerpt

BACKGROUND: Widespread application of massively parallel sequencing has resulted in recognition of clonal hematopoiesis in various clinical settings and on a relatively frequent basis. Somatic mutations occur in individuals with normal blood counts, and increase in frequency with age. The genes affected are the same genes that are commonly mutated in overt myeloid malignancies such as acute myeloid leukemia (AML)...

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PMID: 34263288
DOI: 10.1093/clinchem/hvab105

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