CHIP Happens: Clonal Hematopoiesis of Indeterminate Potential and Its Relationship to Solid Tumors.

doi:10.1158/1078-0432.CCR-22-2598

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Article

CHIP Happens: Clonal Hematopoiesis of Indeterminate Potential and Its Relationship to Solid Tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research - 14 Apr 2023

Reed Sarah C, Croessmann Sarah, Park Ben Ho

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by the expansion of hematopoietic cells harboring leukemia-associated somatic mutations in otherwise healthy people and occurs in at least 10% of adults over 70. It is well established that people with CHIP have increased rates of hematologic malignancy, increased risk of cardiovascular disease, and worse all-cause mortality compared with...

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PMID: 36454121
DOI: 10.1158/1078-0432.CCR-22-2598
PMCID: PMC10106364

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