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Clonal hematopoiesis of indeterminate potential: the root cause of, and fertile ground for, hematological malignancies.

Trends in molecular medicine - 1 Mar 2025

Zhuang Qiqi, Jin Shengjie, Wang Wei, Wang Yan, Tong Hongyan, Liu Zuyun, Sun Jie

Abstract excerpt

Clonal hematopoiesis (CH) of indeterminate potential (CHIP), characterized by propagation of blood cell clones carrying somatic mutations in specific driver genes, is increasingly recognized as a critical factor in the development of hematological malignancies. This phenomenon, which often emerges with age, underscores the complex interplay between genetic predisposition and environmental influences in cancer...

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PMID: 39490273
DOI: 10.1016/j.molmed.2024.10.005

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